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Association between immune cells in peripheral blood and psychiatric symptoms

Juanjuan Yang1, Qian Wang1, Wei Jiang2

  • 1Department of Health Management, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Frontiers in Psychiatry
|July 3, 2023
PubMed

Insights

Individuals with psychiatric symptoms exhibit elevated white blood cell and neutrophil counts. Immune cell differences were more pronounced in those with multiple symptoms, suggesting a link between immunity, psychiatric conditions, and sleep.

Area of Science:

  • Immunology
  • Psychiatry
  • Sleep Science

Background:

  • Bidirectional links exist between immune system dysfunction and psychiatric symptoms.
  • The specific relationship between peripheral immune cell levels and psychiatric symptoms requires further investigation.

Purpose of the Study:

  • To investigate peripheral blood immune cell levels in individuals presenting with psychiatric symptoms.
  • To explore the association between immune cell counts, psychiatric symptom severity, and sleep quality.

Main Methods:

  • Retrospective analysis of routine blood tests, psychopathology, and sleep quality assessments.
  • Comparison of immune cell counts between 45 patients with de novo psychological symptoms and 225 matched controls.

Main Results:

  • Patients with psychiatric symptoms showed higher white blood cell and neutrophil counts than controls.
  • Elevated monocyte counts were observed in patients with multiple psychiatric symptoms.
  • Poorer sleep quality was reported in patients with psychiatric symptoms compared to controls.

Conclusions:

  • Peripheral blood white blood cell and neutrophil counts are significantly higher in patients with psychiatric symptoms.
  • Individuals with multiple psychiatric symptoms displayed more pronounced differences in immune cell profiles.
  • Findings support a connection between psychiatric symptoms, immune function, and sleep quality.
Abstract

Keywords:
anxietyimmunityleukocytepsychiatric symptomssleep

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