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The emerging functions of intraflagellar transport 52 in ciliary transport and ciliopathies

Prajna Udupa1, Debasish Kumar Ghosh1

  • 1Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Traffic (Copenhagen, Denmark)
|January 25, 2024
PubMed

Insights

Intraflagellar transport 52 (IFT52) is vital for ciliary transport and function. Mutations in IFT52 cause ciliopathies, highlighting its role in cellular health and disease.

Area of Science:

  • Cell Biology
  • Genetics

Background:

  • Ciliary transport is essential for eukaryotic cell function, relying on multiprotein intraflagellar transport (IFT) complexes.
  • Intraflagellar transport 52 (IFT52) is a key component of the IFT-B complex, crucial for cargo movement within cilia.

Purpose of the Study:

  • To provide an overview of IFT52's role in ciliary transport mechanisms.
  • To describe IFT52 mutations and their link to various ciliopathies and associated clinical features.

Main Methods:

  • Review of existing literature on IFT52 function and mutations.
  • Analysis of IFT52's role in the IFT-B complex and ciliary component recycling.

Main Results:

  • IFT52 stabilizes IFT-B subcomplexes, regulating ciliary functions like signal transduction.
  • IFT52 mutations disrupt ciliary trafficking, leading to diverse ciliopathies with skeletal, retinal, respiratory, and neurological issues.

Conclusions:

  • IFT52 is critical for maintaining ciliary integrity and function.
  • IFT52 mutations are implicated in a spectrum of ciliopathies, making IFT52 a potential diagnostic biomarker.

Keywords:
IFT complexIFT52ciliopathyintraflagellar transportmutation

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