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CD8+CD60+T Cells and Disease Progression in Children Livingwith HIV

Tamar A Smith-Norowitz1, Haram Abdelmajid2, Yecheskel S Gold2

  • 1Department of Pediatrics, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA tamar.smith-norowitz@downstate.edu.

Annals of Clinical and Laboratory Science
|July 24, 2024
PubMed

Insights

CD8+CD60+ T cells are elevated in children with human immunodeficiency virus-1 (HIV-1) infection. These cells correlate with disease progression, suggesting they may serve as a biomarker for HIV-1 in pediatric patients.

Area of Science:

  • Immunology
  • Virology
  • Pediatrics

Background:

  • CD60 is a T cell marker found on blood lymphocytes.
  • Elevated CD8+CD60+ T cells have been observed in adults with human immunodeficiency virus-1 (HIV-1).
  • The role of CD8+CD60+ T cells in HIV-1 pathogenesis remains unclear.

Purpose of the Study:

  • To investigate the levels of CD8+CD60+ T cells in children with HIV-1.
  • To determine if CD8+CD60+ T cell counts vary across different stages of pediatric HIV-1 disease.
  • To explore the potential of CD8+CD60+ T cells as a marker for HIV-1 progression in children.

Main Methods:

  • Quantitative analysis of CD8+CD60+ T cells using flow cytometry in blood samples.
  • Comparison of CD8+CD60+ T cell counts between HIV-1 positive (N=20) and HIV-1 negative (N=10) children.
  • Categorization of HIV-1 positive children into clinical stages (N, A, B, C) to assess cell counts in relation to disease severity.

Main Results:

  • CD8+CD60+ T cells were significantly higher in HIV-1 positive children compared to HIV-1 negative children (P<0.0001).
  • The highest numbers of CD8+CD60+ T cells were found in the 'C' clinical category of HIV-1 disease.
  • Increased CD8+CD60+ T cell counts were associated with HIV-1 disease progression (P=0.0158).

Conclusions:

  • CD8+CD60+ T cells are elevated in children living with HIV-1.
  • The number of CD8+CD60+ T cells may serve as a potential indicator of HIV-1 disease progression in pediatric populations.
Abstract

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