Related Experiment Video

Updated: Mar 27, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

10.5K

Reed-Sternberg cells express CD161 and lectin-like transcript 1 in Hodgkin lymphoma

Anwar Rjoop1, Rania Al-Samama'h2, Laith Al-Eitan3

  • 1Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Frontiers in Medicine
|March 26, 2026
PubMed

Insights

This study investigated CD161 and Lectin-like transcript 1 (LLT1) expression in Hodgkin lymphoma (HL) Reed-Sternberg cells. No significant association was found with HL subtype, stage, or EBV status, but findings suggest potential for immunotherapy.

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Hodgkin lymphoma (HL) is a B-cell malignancy characterized by Reed-Sternberg (RS) cells.
  • The CD161/LLT1 axis is an emerging immune regulator in cancer, but its role in HL is unclear.

Purpose of the Study:

  • To characterize CD161 and LLT1 expression in HL RS cells.
  • To correlate expression with clinical-pathological features and EBV status.

Main Methods:

  • Immunohistochemistry was used to analyze CD161 and LLT1 expression in 60 HL FFPE samples.
  • Expression patterns and correlations with HL subtype, stage, and EBV status were assessed.

Main Results:

  • LLT1 expression was predominantly cytoplasmic in RS cells.
  • CD161 expression was detected in RS cells at the protein level for the first time.
  • No significant associations were found between CD161/LLT1 expression and HL subtype, stage, or EBV status.

Conclusions:

  • This study provides the first characterization of CD161 and LLT1 in HL RS cells.
  • These molecules may represent potential therapeutic targets for HL immunotherapy.
Abstract

Keywords:
CD161FFPEHodgkin lymphomaImmune RegulationImmunotherapy TargetsLLT1Reed-Sternberg cellsimmunohistochemistry

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