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Crystalline inclusions in myeloid precursors

Marco P Barros Pinto1,2

  • 1Unidade Local de Saúde de Santa Maria, Av. Prof. Egas Moniz, 1649-028, Lisbon, Portugal. marco.pinto@ulssm.min-saude.pt.

Journal of Hematopathology
|June 10, 2026
PubMed

Insights

Crystalline inclusions are found in various blood cells, including those in aggressive myeloid neoplasms. Their presence in myeloid cells may indicate a more severe form of the disease.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Crystalline inclusions are observed in various immune and neoplastic cells.
  • Their significance in myeloid malignancies is not fully understood.

Purpose of the Study:

  • To investigate the association between crystalline inclusions and myeloid neoplasms.
  • To determine if these inclusions are indicative of aggressive disease.

Main Methods:

  • Literature review of cases with crystalline inclusions.
  • Analysis of myeloid cell morphology in diagnosed cases.

Main Results:

  • Crystalline inclusions documented in macrophages, plasma cells, chronic lymphocytic leukemia, and B-cell acute lymphoblastic leukemia.
  • Rare occurrences noted in myeloid precursors.

Conclusions:

  • Crystalline inclusions in myeloid cells may signify aggressive myeloid neoplasms.
  • Further research is warranted to confirm this association.

Keywords:
Acute myeloid leukemiaCrystalline inclusionsLeukemiaMyeloid leukemia

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