Related Experiment Video
Updated: Aug 9, 2026
Murine Model of CD40-activation of B cells
Published on: March 6, 2010
Murine CD38: an immunoregulatory ectoenzyme
F Lund1, N Solvason, J C Grimaldi
1DNAX Research Institute, Palo Alto, CA 94304, USA.
Insights
This study reviews murine CD38, an enzyme on immune cells. It covers CD38 expression, its enzymatic function using NAD+, and how antibodies affect lymphocyte activity, including B-cell proliferation.
Area of Science:
- Immunology
- Biochemistry
- Cell Biology
Background:
- CD38 is an ectoenzyme found on various hematopoietic cells.
- It plays a role in immune cell function and utilizes NAD+.
Purpose of the Study:
- To summarize current knowledge on murine CD38.
- To detail its expression, enzymatic activity, and signaling pathways.
Main Methods:
- Literature review and data synthesis.
- Analysis of published research on CD38.
Main Results:
- CD38 expression is widespread in hematopoietic cells.
- Antibodies targeting CD38 can modulate lymphocyte functions, such as B-cell proliferation.
- The enzymatic activity of CD38 involves NAD+.
Conclusions:
- Murine CD38 is a key molecule in immune cell regulation.
- Understanding CD38's pathways is crucial for immunology research.
Abstract:
CD38 is an ectoenzyme that utilizes NAD+ and is expressed by many cells of hematopoietic origin. Antibodies to CD38 potentiate many biological activities on lymphocytes, including induction of murine B-cell proliferation. In this article, Frances Lund and colleagues summarize information concerning the expression, enzymatic activity and signal transduction pathway utilized by murine CD38.
