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Mantle-cell lymphoma in a patient with human immunodeficiency viral infection

S Bilgrami1, N Shafi, E L Pesanti

  • 1Department of Medicine, Veterans Affairs Medical Center, Newington, Conn., USA.

Acta Haematologica
|January 1, 1995
PubMed

Insights

This is the first reported case of mantle-cell lymphoma in a patient with human immunodeficiency virus (HIV). The aggressive cancer showed poor response to chemotherapy, with the patient surviving only four months.

Area of Science:

  • Hematology
  • Oncology
  • Infectious Diseases

Background:

  • Low-grade lymphomas are rarely observed in patients with human immunodeficiency virus (HIV).
  • Mantle-cell lymphoma is a specific type of low-grade non-Hodgkin lymphoma.

Observation:

  • A patient with HIV infection presented with lymphocytosis, lymphadenopathy, and splenomegaly.
  • The lymphoma involved the bone marrow and meninges.

Findings:

  • This case represents the first documented instance of mantle-cell lymphoma co-occurring with HIV infection.
  • The lymphoma exhibited an unusually aggressive clinical course.
  • Chemotherapy provided an insignificant response, leading to a short survival period of 4 months.

Implications:

  • This case highlights the potential for aggressive presentations of mantle-cell lymphoma in HIV-infected individuals.
  • Further research is needed to understand the interplay between HIV and mantle-cell lymphoma pathogenesis.
  • Investigating novel therapeutic strategies for this aggressive lymphoma in the context of HIV is crucial.

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