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Type D SRV-2 virus-specific CD8+ and CD4- CD8- T cells that regulate virus-induced T cell proliferation in Celebes

A Malley1, N Pangares, S K Mayo

  • 1Oregon Regional Primate Research Center, Beaverton 97006.

Journal of Medical Primatology
|February 1, 1993
PubMed

Insights

Simian retrovirus type 2 (SRV-2) envelope peptides were identified as T cell epitopes. In infected Celebes macaques, SRV-2 exposure led to suppressed T cell responses and distinct immunoregulatory T cell populations.

Area of Science:

  • Immunology
  • Virology
  • Primate research

Background:

  • Simian retrovirus type 2 (SRV-2) is a significant pathogen in macaques.
  • Understanding the immune response to SRV-2 is crucial for disease management and vaccine development.

Purpose of the Study:

  • To define T cell epitopes within the SRV-2 envelope.
  • To investigate T cell responses in SRV-2 infected Celebes macaques (Macaca nigra).

Main Methods:

  • Identification of SRV-2 envelope peptides (96-102, 127-152, 233-249) as T cell epitopes.
  • Culture of peripheral blood lymphocytes from SRV-2 exposed macaques with SRV-2 virus.
  • Analysis of T cell proliferation and identification of immunoregulatory T cell populations.

Main Results:

  • SRV-2 envelope peptides 96-102, 127-152, and 233-249 induced significant T cell proliferation.
  • Peripheral blood lymphocytes from SRV-2 exposed, antibody-positive macaques showed suppressed T cell responses when cultured with SRV-2.
  • Two distinct immunoregulatory T cell populations were identified in these animals.

Conclusions:

  • Specific SRV-2 envelope peptides act as T cell epitopes.
  • SRV-2 infection in Celebes macaques is associated with suppressed T cell immunity and the presence of regulatory T cells.

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