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Mammary fibroadenoma in a young Holstein cow
1Department of Veterinary Surgery, Faculty of Agriculture, Miyazaki University, Japan.
Insights
A large mammary mass in a Holstein cow was surgically removed. Histological and immunohistochemical analysis revealed features consistent with fibroadenoma, a type of mammary tumor.
Area of Science:
- Veterinary Pathology
- Bovine Medicine
- Surgical Oncology
Background:
- Mammary masses in cattle can impact animal health and productivity.
- Understanding the nature of these masses is crucial for diagnosis and treatment.
Observation:
- A 60 cm diameter mammary mass was surgically excised from a 17-month-old Holstein cow's left udder.
- The mass was well-demarcated with a lobular cut surface.
- Microscopic examination revealed well-differentiated ducts and mucinous connective tissue.
Findings:
- Immunohistochemistry identified vimentin-positive fibroblasts and vimentin/actin-positive spindle cells in the stroma surrounding the ducts.
- These cellular features are characteristic of fibroadenoma.
Implications:
- The findings suggest mammary fibroadenoma can occur in cattle.
- This case expands the comparative understanding of mammary tumors across species.
- Further research into bovine mammary tumors is warranted.
Abstract:
A mammary mass approximately 60 cm in diameter, which developed in the left udder of a 17-month-old Holstein cow, was removed surgically. The mass was well demarcated from the surrounding tissues and its cut surface was lobular in appearance. Microscopically, the mass consisted of a proliferation of well differentiated ducts and mucinous connective tissue. Immunohistochemically, the proliferative stroma contained two distinct cell types; vimentin-positive fibroblasts and spindle cells positive for vimentin and actin at the periphery of the ducts. The biological features of the present mammary tumor are thought to be generally compatible with those of mammary fibroadenoma reported in humans and dogs.