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Elevated concentrations of circulating ICAM-1 in far advanced and miliary tuberculosis

N Shijubo1, K Imai, F Nakanishi

  • 1Department of Internal Medicine, Sapporo Medical University, Japan.

The American Review of Respiratory Disease
|November 1, 1993
PubMed

Insights

Circulating Intercellular Adhesion Molecule-1 (ICAM-1) levels are elevated in severe tuberculosis cases. Measuring ICAM-1 can help assess tuberculosis severity and monitor treatment effectiveness.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Biochemistry

Background:

  • Intercellular Adhesion Molecule-1 (ICAM-1) is crucial in inflammatory responses.
  • Cytokines like tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) increase ICAM-1 expression and shedding.
  • Tuberculosis (TB) is a significant global health issue often involving inflammatory processes.

Purpose of the Study:

  • To investigate the role of circulating ICAM-1 in patients with tuberculosis.
  • To correlate ICAM-1 levels with disease severity and specific cytokine concentrations.
  • To evaluate ICAM-1 as a potential biomarker for monitoring TB treatment.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure serum ICAM-1 concentrations.
  • Serum levels of IFN-gamma and TNF-alpha were also quantified.
  • Patient groups were categorized by TB disease stage (minimal, moderate, far advanced, miliary).

Main Results:

  • Significantly elevated circulating ICAM-1 levels were observed in miliary and far advanced pulmonary tuberculosis.
  • High concentrations of IFN-gamma and TNF-alpha correlated with advanced TB stages.
  • Circulating ICAM-1 levels showed a significant positive correlation with serum IFN-gamma and TNF-alpha.
  • Successful antituberculous drug treatment led to a decrease in ICAM-1 concentrations, correlating with clinical improvement.

Conclusions:

  • Circulating ICAM-1 is a valuable biomarker for assessing the severity of tuberculosis.
  • Monitoring ICAM-1 levels can aid in evaluating disease activity and treatment response in TB patients.
  • ICAM-1 measurement offers a potential tool for managing tuberculosis patients.

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