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Ki-1 large cell anaplastic lymphoma--a clinicopathological study
Insights
This study reviews 10 Ki-1 large cell anaplastic lymphoma cases, detailing clinical and morphological features. Ki-1 lymphoma, a malignant lymphoma variant, often presents as cervical lymphadenopathy and shows pleomorphic morphology.
Area of Science:
- Oncology
- Hematopathology
- Immunohistochemistry
Background:
- Ki-1 large cell anaplastic lymphoma is an emerging variant of malignant lymphoma.
- Understanding its clinical and morphological characteristics is crucial for diagnosis.
Purpose of the Study:
- To retrospectively analyze 10 cases of Ki-1 lymphoma.
- To document the clinical and morphological features of this lymphoma variant.
Main Methods:
- Retrospective review of 10 Ki-1 lymphoma cases.
- Morphological evaluation of hematoxylin and eosin stained paraffin-embedded sections.
- Immunohistochemical staining for BER-H2 and leucocyte common antigen (LCA).
Main Results:
- Patient age ranged from 2 to 60 years, with a male to female ratio of 2.3:1.
- Cervical lymphadenopathy was the most frequent clinical presentation.
- Histologically, 8 cases showed effaced lymph node architecture; 2 had Reed-Sternberg-like cells and 7 had histiocyte-like cells.
- All cases tested positive for BER-H2 via immunohistochemistry.
Conclusions:
- Ki-1 lymphoma exhibits diverse morphological features.
- BER-H2 positivity is a consistent finding in Ki-1 lymphoma.
- Consideration of Ki-1 lymphoma is recommended for lymphomas with pleomorphic morphology.
Abstract:
Ki-1 large cell anaplastic lymphoma is a recently described variant of malignant lymphoma. A retrospective study of 10 cases of Ki-1 lymphoma was carried out at the Armed Forces Institute of Pathology (AFIP) Rawalpindi to document its clinical and morphological features. The morphological features were evaluated by a study of paraffin embedded sections stained with haematoxylin and eosin stains. Immunohistochemical stains for BER-H2 and leucocyte common antigen (LCA) were performed in all cases. The age of the patients ranged from 2 to 60 years and male to female ratio was 2.3:1. Cervical lymphadenopathy was the most common presentation. Histologically, there was a complete effacement of the lymph node architecture in 8 cases. The Reed-Sternberg like cells were seen in 2 and histiocyte like cells in 7 cases. Immunohistochemically all cases were positive for BER-H2. It is suggested that the possibility of Ki-1 lymphoma should be considered in all cases of lymphoma with pleomorphic morphology.
