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Regulation of lymphocyte activation by the cell-surface molecule CD22

C L Law1, S P Sidorenko, E A Clark

  • 1Dept of Microbiology, University of Washington, Seattle 98195.

Immunology Today
|September 1, 1994
PubMed

Insights

Accessory molecules like CD22 regulate B-cell antigen receptor (BCR) activation. This review explores CD22

Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • Accessory molecules are crucial for lymphocyte activation.
  • The B-cell antigen receptor (BCR) pathway is central to adaptive immunity.
  • CD22 is an accessory molecule expressed on B-lineage cells.

Purpose of the Study:

  • To review the structure-function relationship between CD22 and the BCR.
  • To discuss the role of CD22 as a cell-adhesion molecule.
  • To propose models for the in vivo functions of CD22.

Main Methods:

  • Literature review of current knowledge.
  • Analysis of structural and functional data.
  • Development of theoretical models.

Main Results:

  • CD22 interacts with the BCR, influencing its signaling.
  • CD22 functions as a cell-adhesion molecule.
  • Potential in vivo roles for CD22 are proposed.

Conclusions:

  • Understanding the CD22-BCR interaction is key to B-cell regulation.
  • CD22's dual role as a signaling modulator and adhesion molecule is highlighted.
  • Further research into CD22's in vivo functions is warranted.

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