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Increased lactic dehydrogenase (LDH)-linked immunoglobulin associated with interferon-alpha therapy in a case of

S Nabeshima1, J Hayashi, M Hirata

  • 1Department of General Medicine, Kyushu University Hospital, Fukuoka.

Internal Medicine (Tokyo, Japan)
|July 1, 1994
PubMed

Insights

Interferon-alpha (IFN-alpha) treatment for chronic hepatitis C can elevate lactate dehydrogenase (LDH) levels due to LDH-linked immunoglobulin complexes. Testing for these complexes is recommended for patients on IFN therapy experiencing elevated LDH.

Area of Science:

  • Hepatology
  • Immunology
  • Biochemistry

Background:

  • Chronic hepatitis C is a significant global health concern.
  • Interferon-alpha (IFN-alpha) has been a treatment modality for hepatitis C.
  • Monitoring treatment-related biochemical changes is crucial.

Observation:

  • A patient receiving IFN-alpha for chronic hepatitis C developed elevated serum lactate dehydrogenase (LDH).
  • LDH levels normalized upon discontinuation of IFN-alpha.
  • No significant worsening of liver histopathology or function was observed.

Findings:

  • Elevated LDH during IFN-alpha therapy correlated with the presence of LDH-linked immunoglobulin.
  • LDH-linked immunoglobulin is a complex that can cause elevated LDH levels.
  • This complex formation is a potential mechanism for IFN-alpha-induced hyperlactatedehydrogenemia.

Implications:

  • Clinicians should consider testing for LDH-linked immunoglobulin in hepatitis C patients on IFN-alpha therapy with elevated LDH.
  • Identifying LDH-linked immunoglobulin can help differentiate treatment effects from disease progression.
  • This finding may inform management strategies for patients undergoing IFN-based therapies.

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