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Soluble ICAM-1 levels in serum during acute infectious mononucleosis

S Furukawa1, T Motohashi, T Matsubara

  • 1Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.

Scandinavian Journal of Infectious Diseases
|January 1, 1993
PubMed

Insights

Soluble intercellular adhesion molecule-1 (ICAM-1) levels rise during acute infectious mononucleosis (IM). This increase correlates with more activated immune cells, suggesting ICAM-1 regulates immune responses in IM.

Area of Science:

  • Immunology
  • Virology
  • Biochemistry

Background:

  • Intercellular adhesion molecule-1 (ICAM-1) is recognized as an activation antigen on immune cells like T-cells, B-cells, macrophages, and monocytes.
  • Understanding the role of ICAM-1 in viral infections is crucial for immune response modulation.

Purpose of the Study:

  • To investigate the levels of soluble ICAM-1 in serum during the acute phase of infectious mononucleosis (IM).
  • To explore the correlation between serum ICAM-1 levels and peripheral blood mononuclear cell counts in IM patients.

Main Methods:

  • Serum samples were collected from 11 patients during the acute stage of IM.
  • Soluble ICAM-1 levels were quantified using a double determinant immunoassay with monoclonal antibodies on the FAST system.

Main Results:

  • Serum ICAM-1 levels were significantly elevated in patients during the acute stage of IM.
  • A positive correlation was observed between increased serum ICAM-1 levels and higher absolute counts of peripheral blood mononuclear cells.

Conclusions:

  • Elevated serum ICAM-1 levels in acute IM are associated with an increased number of activated peripheral blood mononuclear cells.
  • ICAM-1 appears to play a role in the regulatory mechanisms of immune reactions during acute infectious mononucleosis.

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