Related Experiment Video

Updated: Aug 8, 2026

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
11:50

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

Cytokine technology in basic and applied research on the hematopoietic system

R V House1

  • 1Life Sciences Research, IIT Research Institute, Chicago, Illinois 60616.

Toxicologic Pathology
|January 1, 1993
PubMed

Insights

Cytokines are key polypeptide molecules regulating immunity and hematopoiesis. Cytokine technology utilizes these molecules as research tools to explore cellular and molecular regulation in biomedical research.

Area of Science:

  • Biomedical Research
  • Immunology
  • Hematopoiesis

Background:

  • Cytokines are crucial polypeptide molecules.
  • They play a vital role in regulating immunity and hematopoiesis.
  • Their function makes them significant in basic and applied biomedical research.

Purpose of the Study:

  • To provide an overview of the basic and applied biology of cytokines.
  • To introduce and define "cytokine technology" as a research approach.
  • To review advanced technologies for studying cytokine function.

Main Methods:

  • Literature review of basic and applied cytokine biology.
  • Conceptualization and definition of "cytokine technology".
  • Review of frontier technologies: fusion toxins, fusion proteins, and animal models.

Main Results:

  • Cytokines are essential regulators of physiological mechanisms.
  • "Cytokine technology" offers a framework for using cytokines as research tools.
  • Advanced technologies enhance the study of cytokine expression and regulation.

Conclusions:

  • Cytokines are fundamental to immune and hematopoietic systems.
  • Cytokine technology is a valuable approach for understanding cellular and molecular regulation.
  • Emerging technologies provide powerful methods for cytokine research.

More Related Videos

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Preparation of Whole Bone Marrow for Mass Cytometry Analysis of Neutrophil-lineage Cells08:09

Preparation of Whole Bone Marrow for Mass Cytometry Analysis of Neutrophil-lineage Cells

Published on: June 19, 2019

Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...