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[Studies on the gamma delta T lymphocytes in the peripheral blood in healthy adults]

M Ishizawa1, Y Yuki, N Fujita

  • 1Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|March 1, 1993
PubMed

Insights

Gamma delta T lymphocytes, crucial in immunology, were quantified in 151 healthy adults. Their numbers slightly decrease with age but show no significant sex-based differences.

Area of Science:

  • Immunology
  • Cell Biology
  • Flow Cytometry

Context:

  • Gamma delta T lymphocytes are implicated in various immunological disorders.
  • Clinical need exists to establish normal ranges for these cells in peripheral blood.
  • Understanding normal cell populations is vital for diagnosing immune system abnormalities.

Purpose:

  • To determine the normal population of gamma delta T lymphocytes in healthy adults.
  • To establish reference ranges for cell counts across different age groups.
  • To investigate potential correlations between cell numbers and demographic factors like age and sex.

Summary:

  • 151 healthy volunteers aged 20-69 years were analyzed using dual-color flow cytometry.
  • Gamma delta T lymphocytes constituted 3.8 +/- 2.5% of peripheral blood lymphocytes (range: 0.6-16.1%).
  • A significant inverse correlation was observed between gamma delta T cell counts and increasing age, with no significant sex-based differences.

Impact:

  • Provides essential reference values for gamma delta T lymphocyte populations in healthy individuals.
  • Aids in the diagnosis and monitoring of immunological disorders.
  • Contributes to a deeper understanding of T cell subset dynamics throughout the lifespan.

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