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Leukaemia cutis in chronic CD8+ T lymphocytic leukaemia
H Kishimoto1, A Mamada, I Katayama
1Department of Dermatology, School of Medicine, Tokyo Medical and Dental University, Japan.
Insights
A rare case of CD8+ chronic lymphocytic leukemia (CLL) presented as skin plaques. This leukemia cutis, characterized by diffuse CD8+ cell infiltration, is previously unreported.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Chronic lymphocytic leukemia (CLL) is a heterogeneous lymphoid malignancy.
- Leukemia cutis refers to the infiltration of the skin by leukemic cells.
- CD8+ T-cell involvement in CLL is less common than B-cell involvement.
Observation:
- A 66-year-old woman with known CD8+ CLL developed multiple indurated skin lesions.
- Skin biopsy revealed dense infiltration of the dermis and subcutaneous tissue by leukemic cells.
- The majority of infiltrating cells were identified as CD8+ T-cells.
Findings:
- The patient presented with a unique manifestation of leukemia cutis.
- The skin lesions were characterized by plaques with diffuse infiltration of CD8+ leukemic cells.
- This specific presentation of CD8+ CLL leukemia cutis has not been previously documented in medical literature.
Implications:
- This case expands the known clinical spectrum of CD8+ CLL.
- It highlights the importance of considering cutaneous involvement in CD8+ CLL.
- Further research may be needed to understand the pathogenesis and clinical significance of CD8+ T-cell leukemia cutis.
Abstract:
A 66-year-old woman with CD8+ chronic lymphocytic leukaemia developed multiple indurated erythema or plaques. A skin biopsy specimen showed dense infiltration of leukaemia cells in the dermis and subcutaneous tissue. Most of the infiltrating cells were CD8 + cells. To our best knowledge, leukaemia cutis such as this case showing plaques with diffuse infiltration of CD8 + cells has not been reported previously.