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[Urinary porphyrin excretion in human immunodeficiency virus infection]

F Mouly1, M Janier, Y Nordmann

  • 1Policlinique de Dermatologie, Hôpital Saint-Louis, Paris.

Presse Medicale (Paris, France : 1983)
|October 26, 1996
PubMed

Insights

Human immunodeficiency virus (HIV) infection is not directly linked to altered porphyrin metabolism. Liver disorders, common in HIV patients, are more likely causes of these metabolic changes.

Area of Science:

  • Biochemistry
  • Virology
  • Hepatology

Context:

  • Porphyria cutanea tarda (PCT) is a known complication in some human immunodeficiency virus (HIV) patients.
  • Previous reports indicate PCT in approximately 60 HIV-infected individuals since 1987.
  • The role of HIV infection in porphyrin metabolism disorders, beyond overt PCT, remains unclear.

Purpose:

  • To investigate porphyrin metabolism disorders in HIV-infected patients without clinically apparent PCT.
  • To assess urinary porphyrin excretion patterns in a cohort of HIV-positive individuals.

Summary:

  • Urinary porphyrin levels were analyzed in 64 HIV-infected patients.
  • Abnormal porphyrin excretion was detected in 36% of patients, with 6% showing patterns suggestive of PCT.
  • Increased coproporphyrinuria was observed in 23% of patients.
  • Abnormalities were more prevalent in patients with existing liver disease or advanced HIV/AIDS.
  • One patient later developed PCT, two years after the initial assessment.

Impact:

  • HIV infection itself may not directly cause altered porphyrin metabolism.
  • The high frequency of liver disorders in HIV patients likely contributes to observed porphyrin abnormalities.
  • Findings suggest that underlying hepatopathy is a significant factor in porphyrin metabolism disturbances among HIV-infected individuals.
Abstract

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