Related Experiment Videos
Malignant lymphoma of the transverse colon associated with macroglobulinemia
O Yasui1, F Tukamoto, N Sasaki
1Akita Rosai Hospital and Department of Pathology of the University of Akita, School of Medicine, Oodate City, Japan.
Insights
This case report details a rare instance of transverse colon lymphoma linked to Waldenström macroglobulinemia. The study highlights the diagnostic journey and pathological confirmation of this dual condition.
Area of Science:
- Oncology
- Hematology
- Gastroenterology
Background:
- Malignant lymphomas can present with extranodal involvement, including the gastrointestinal tract.
- Waldenström macroglobulinemia is a rare lymphoproliferative disorder characterized by monoclonal IgM production.
Observation:
- A 73-year-old male incidentally found to have elevated serum gamma-globulin levels.
- Diagnostic workup revealed a transverse colon tumor and significantly high IgM levels (3490 mg/dl) with kappa-type Bence-Jones protein in urine.
Findings:
- Histopathological examination confirmed a small lymphocytic non-Hodgkin lymphoma of B-cell origin in the transverse colon.
- Flow cytometry analysis showed tumor cells positive for IgM-kappa, indicating monoclonal IgM production by the lymphoma cells.
Implications:
- This case underscores the importance of considering gastrointestinal lymphoma in patients presenting with Waldenström macroglobulinemia.
- The findings contribute to understanding the association between specific lymphoma subtypes and monoclonal gammopathies.
Abstract:
We present an unusual case of a malignant lymphoma of the transverse colon associated with macroglobulinemia. A 73-yr-old man was incidentally discovered to have high serum gamma-globulin on a regular check-up. Serum immunoquantitation revealed an IgM level of 3490 mg/dl. Kappa-type Bence-Jones protein was positive in the urine. Immunoelectrophoresis identified the abnormal protein as IgM-kappa. After hospitalization an abdominal tumor was detected with barium and CT, identified as a tumor of the transverse colon. Partial resection of the transverse colon was carried out. Histopathologically the tumor were confirmed as small lymphocytic non-Hodgkin lymphoma of B-cell origin, based on the Working Formulation. According to flowcytometric analysis, the tumor cells were positive for IgM-kappa. The lymphoma cells produced monoclonal IgM, giving rise to macroglobulinemia.