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CD23/Fc epsilon RII: signaling and clinical implication

M D Mossalayi1, M Arock, P Debré

  • 1Groupe d'Immuno-hématologie Moléculaire, CNRS URA625, Hôpital de La Pitié-Salpêtrière, Paris, France.

International Reviews of Immunology
|January 1, 1997
PubMed

Insights

CD23, a receptor for IgE, triggers functions via intracellular signaling pathways. Soluble CD23 and its ligands activate cyclic nucleotide and nitric oxide pathways in various cells, impacting immune responses.

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • CD23, the low-affinity IgE receptor (Fc epsilon RII), is expressed on hematopoietic and epithelial cells.
  • Both membrane-bound and soluble CD23 interact with multiple ligands.
  • These interactions initiate diverse cellular functions in human and murine systems.

Purpose of the Study:

  • To elucidate intracellular signaling events triggered by soluble CD23.
  • To identify ligands involved in CD23-mediated signaling in target cells.
  • To explore the role of CD23 signaling in various physiological and pathological conditions.

Main Methods:

  • Discussion of intracellular signaling pathways.
  • Analysis of ligand-receptor interactions.
  • Review of recent in vivo data.

Main Results:

  • Soluble CD23 induces intracellular signaling cascades.
  • Ligand binding to CD23 activates specific pathways in target cells.
  • CD23 ligation on cell surfaces links to cyclic nucleotide and nitric oxide (NO) pathways.

Conclusions:

  • CD23 signaling plays a regulatory role in immune functions.
  • These signals are implicated in hematopoiesis, anti-tumoral defense, and inflammation.
  • CD23 pathways are relevant to allergy, microbicidal activity, skin diseases, and HIV infection.

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