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Videos de Conceptos Relacionados

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis
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An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis

Published on: September 15, 2015

Proteómica para el estudio de genes y genomas.

A Pandey1, M Mann

  • 1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142, USA.

Nature
|June 24, 2000
PubMed
Resumen
Este resumen es generado por máquina.

La proteómica, el estudio a gran escala de las proteínas, ayuda a comprender la función génica. Implica la identificación de proteínas, la visualización diferencial y los estudios de interacción, ofreciendo una promesa significativa para la investigación biológica y de enfermedades.

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

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An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis
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An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis

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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Área de la Ciencia:

  • La bioquímica es la bioquímica.
  • Biología Molecular Biología Molecular
  • La genómica es la genómica.

Sus antecedentes:

  • La era post-genómica requiere métodos avanzados para comprender la función de los genes.
  • El análisis de proteínas, o proteómica, es crucial para elucidar los procesos biológicos.
  • Predecir la función de la proteína únicamente a partir de la secuencia o la estructura puede ser un desafío.

Objetivo del estudio:

  • Para resaltar la importancia de la proteómica en la comprensión de la función génica.
  • Para esbozar las áreas clave y las aplicaciones de la proteómica.
  • Para enfatizar el potencial de la proteómica en el análisis funcional del proteoma.

Principales métodos:

  • Microcaracterización de proteínas para la identificación de proteínas a gran escala y el análisis de la modificación.
  • Proteómica de visualización diferencial para comparar los niveles de expresión de proteínas.
  • Estudios de interacción proteína-proteína utilizando técnicas como la espectrometría de masas y los sistemas de dos híbridos de levadura.

Principales resultados:

  • La proteómica ofrece un enfoque multifacético para el análisis de proteínas.
  • La proteómica de visualización diferencial tiene aplicaciones potenciales en la investigación de enfermedades.
  • La identificación de los componentes de los complejos proteicos es fundamental para el análisis proteómico funcional.

Conclusiones:

  • La proteómica es un campo vital para avanzar en nuestra comprensión de los sistemas biológicos.
  • El estudio de los complejos proteicos y las estructuras celulares es muy prometedor.
  • La proteómica contribuirá significativamente a la comprensión de la bioquímica, los procesos y las vías de las proteínas.