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Videos de Conceptos Relacionados

Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
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La regulación genética en la tercera dimensión.

Job Dekker1

  • 1Program in Gene Function and Expression and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605-0103, USA. Job.Dekker@umassmed.edu

Science (New York, N.Y.)
|March 29, 2008
PubMed
Resumen

Los cromosomas forman complejas redes de interacción 3D que regulan la expresión génica. Comprender cómo ocurren estas interacciones cromosómicas y su impacto funcional es crucial para descifrar la regulación génica.

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Área de la Ciencia:

  • La genómica es la genómica.
  • Biología Molecular Biología Molecular
  • La epigenética es la epigenética.

Sus antecedentes:

  • Los cromosomas exhiben una organización espacial intrincada dentro del núcleo celular.
  • Esta organización tridimensional (3D) influye en la regulación de los genes.
  • Comprender las interacciones cromosómicas es clave para comprender la función del genoma.

Objetivo del estudio:

  • Para analizar la organización espacial de los cromosomas.
  • Para investigar el impacto de las interacciones cromosómicas en la expresión génica.
  • Para identificar los desafíos en la comprensión de los mecanismos y las consecuencias funcionales de estas interacciones.

Principales métodos:

  • Análisis de la organización espacial cromosómica.
  • Investigando las redes de interacción cromosómica 3D.
  • Examinar los efectos sobre la expresión génica, incluida la actividad potenciadora/represora y las modificaciones epigenéticas.

Principales resultados:

  • Se han identificado complejas redes 3D de interacciones cromosómicas.
  • Estas interacciones influyen en la expresión génica en múltiples niveles.
  • El control de largo alcance por potenciadores/represores y la expresión génica coordinada se ven afectados.

Conclusiones:

  • La organización espacial cromosómica juega un papel importante en la regulación de los genes.
  • Descifrar los mecanismos de la asociación del locus es un gran desafío.
  • Comprender las consecuencias funcionales de las asociaciones cromosómicas transitorias es esencial.