Video Experimental Relacionado
Updated: Jul 6, 2026
10:46
Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
Published on: October 18, 2022
Evolución de los circuitos de transcripción de los eucariotas
Brian B Tuch1, Hao Li, Alexander D Johnson
1Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
Science (New York, N.Y.)
|March 29, 2008
Resumen
Los cambios evolutivos en la regulación genética impulsan la diversidad de la vida. Incluso las especies estrechamente relacionadas exhiben diferencias significativas en sus circuitos de transcripción, como revelan estudios recientes de todo el genoma.
Área de la Ciencia:
- Biología evolutiva Biología evolutiva.
- Biología molecular La biología molecular.
- La genómica es la genómica.
Sus antecedentes:
- La modificación evolutiva de los circuitos de transcripción es un factor clave de la diversidad biológica.
- Los estudios en animales demuestran cómo los cambios menores en la regulación de los genes impactan la morfología y la fisiología bajo presiones selectivas.
Objetivo del estudio:
- Para investigar el grado de recableado transcripcional a través de diferentes organismos.
- Comprender el papel de la regulación génica en la diversificación evolutiva.
Principales métodos:
- Estudios de todo el genoma.
- Análisis comparativo de la regulación transcripcional en especies estrechamente relacionadas, con un enfoque en levaduras unicelulares.
Principales resultados:
- La evidencia de un extenso recableado transcripcional descubierto en estudios de todo el genoma.
- Los organismos estrechamente relacionados utilizan circuitos reguladores de genes marcadamente diferentes.
Conclusiones:
- El recableado transcripcional juega un papel importante en la evolución de la diversidad de la vida.
- La regulación génica es un proceso dinámico que puede cambiar ampliamente incluso entre especies relacionadas.
Más Videos Relacionados
Videos de Conceptos Relacionados
01:53Bacterial Transcription
RNA polymerase (RNAP) carries out DNA-dependent RNA synthesis in both bacteria and eukaryotes. Bacteria do not have a membrane-bound nucleus. So, transcription and translation occur simultaneously, on the same DNA template.
Transcription can be divided into three main stages, each involving distinct DNA sequences to guide the polymerase. These are:
Transcription can be divided into three main stages, each involving distinct DNA sequences to guide the polymerase. These are:
02:42Eukaryotic Transcription Activators
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These domains are...
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These domains are...
02:40The Eukaryotic Promoter Region
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences. The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
02:40The Eukaryotic Promoter Region
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences. The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
02:36RNA Polymerase II Accessory Proteins
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
01:52Eukaryotic Transcription Inhibitors
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a DNA...
Eukaryotic transcription inhibitors usually contain two distinct domains, a DNA...