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In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
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Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
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Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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Ions - When an atom participates in a chemical reaction that results in the donation or acceptance of one or more electrons, the atom becomes positively or negatively charged. This frequently happens for most atoms to have a full valence shell. This can happen either by gaining electrons to fill a shell that is more than half-full or by giving away electrons to empty a shell that is less than half-full, thereby leaving the next smaller electron shell as the new, full valence shell. An atom with...
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Video Experimental Relacionado

Updated: Feb 13, 2026

Determination of Tripartite Interaction between Two Monomers of a MADS-box Transcription Factor and a Calcium Sensor Protein by BiFC-FRET-FLIM Assay
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Las moléculas de la locura.

Solomon H Snyder1

  • 1The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ssnyder@jhmi.edu

Cell
|January 13, 2010
PubMed
Resumen

Esta narración explora un viaje científico de cinco décadas desde la psiquiatría hasta la neuroquímica. Ofrece información para jóvenes científicos que navegan por diversos intereses de investigación en neurociencia y farmacología.

Área de la Ciencia:

  • La neurociencia es la neurociencia.
  • La psiquiatría es la psiquiatría.
  • La bioquímica es la bioquímica.

Sus antecedentes:

  • La trayectoria profesional del autor evolucionó a partir de un interés inicial en la psiquiatría y la mente humana.
  • Esta trayectoria condujo a investigaciones bioquímicas en profundidad de neurotransmisores y agentes farmacológicos.

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