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Los genomas del cáncer evolucionan pulverizando los cromosomas individuales
Matthew Meyerson1, David Pellman
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. matthew_meyerson@dfci.harvard.edu
Cell
|January 11, 2011
Resumen
Un nuevo mecanismo de cáncer llamado cromotripsis implica una ruptura y reensamblaje de cromosomas. Este evento de inestabilidad genética plantea preguntas sobre cómo los segmentos del genoma se dirigen durante este proceso.
Área de la Ciencia:
- Genética La genética.
- Biología del cáncer Biología del cáncer.
- La genómica es la genómica.
Sus antecedentes:
- Un nuevo mecanismo denominado cromotripsis ha sido identificado como una fuente de inestabilidad genética en el cáncer.
- La cromotripsis implica la fragmentación catastrófica y el posterior reensamblaje de un solo cromosoma.
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