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Pequeños genes ocultos dentro de nuestro microbioma

Karin Mittelman¹, David Burstein¹

¹School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.

|August 24, 2019

Resumen

Este resumen es generado por máquina.

Los investigadores descubrieron miles de familias de genes conservados que codifican pequeñas proteínas en el microbioma humano. Estas pequeñas proteínas son cruciales para la comunicación bacteriana y las interacciones del huésped.

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Área de la Ciencia:

Microbiología
La genómica
Proteomía

Sus antecedentes:

El microbioma humano comprende billones de microorganismos.
Los análisis genómicos tradicionales a menudo pasan por alto pequeñas secuencias de codificación de proteínas.
Comprender las interacciones microbianas es vital para la salud humana.

Objetivo del estudio:

Para explorar el paisaje de pequeñas secuencias de codificación de proteínas en el microbioma humano.
Para identificar las familias de genes conservados que codifican estas pequeñas proteínas.
Investigar las funciones potenciales de las pequeñas proteínas en las interacciones microbianas y del huésped.

Principales métodos:

Análisis bioinformático de los datos genómicos del microbioma humano.
Identificación y clasificación de las familias de proteínas pequeñas conservadas.
Genómica comparativa para evaluar la conservación entre las diferentes especies microbianas.

Principales resultados:

Descubrimiento de miles de familias de genes conservados que codifican pequeñas proteínas.
Estas familias de genes fueron previamente pasadas por alto por los métodos analíticos estándar.
La evidencia sugiere que estas pequeñas proteínas están muy extendidas en todo el microbioma.

Conclusiones:

El microbioma humano alberga un vasto repertorio de pequeñas proteínas sin caracterizar.
Estas pequeñas proteínas probablemente juegan un papel importante en la comunicación bacteriana entre especies (crosstalk).
Las proteínas pequeñas representan una nueva interfaz para las interacciones huésped-microbioma.