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Las bacterias patógenas modulan la respuesta de las feromonas para promover el apareamiento
Taihong Wu1,2, Minghai Ge1,2, Min Wu1,2
1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Nature
|January 4, 2023
Resumen
Los patógenos pueden cambiar el comportamiento social de los animales. En los gusanos C. elegans, un patógeno bacteriano altera el comportamiento de apareamiento al cambiar la forma en que los gusanos perciben las feromonas, promoviendo la reproducción y la adaptación.
Área de la Ciencia:
- La neurociencia
- Ecología del comportamiento
- Microbiología
Sus antecedentes:
- Las interacciones huésped-patógeno influyen significativamente en los comportamientos sociales de los animales.
- Los mecanismos neuronales que impulsan los cambios de comportamiento social inducidos por patógenos siguen siendo en gran medida desconocidos.
Objetivo del estudio:
- Para investigar la base neuronal de la plasticidad del comportamiento social inducida por patógenos en Caenorhabditis elegans.
- Para entender cómo los patógenos bacterianos modulan las interacciones sociales y el comportamiento de apareamiento.
Principales métodos:
- Exposición de hermafroditas adultos de C. elegans a Pseudomonas aeruginosa.
- Análisis de la expresión del quimiorreceptor STR-44 en las neuronas sensoriales AWA.
- Evaluación de la respuesta de las feromonas y el comportamiento de apareamiento tras la exposición al patógeno.
Principales resultados:
- La exposición al patógeno indujo la expresión de STR-44 en las neuronas AWA, alterando la evitación de feromonas.
- STR-44 en las neuronas AWA es esencial para los cambios inducidos por el patógeno en la respuesta de las feromonas.
- C. elegans hermafroditas aumentaron las tasas de apareamiento con machos después de la exposición al patógeno, dependiendo de STR-44.
Conclusiones:
- La plasticidad inducida por patógenos en el comportamiento social está mediada por el quimiorreceptor STR-44 en C. elegans.
- Este mecanismo promueve la diversidad genética y la adaptación del huésped al aumentar las tasas de apareamiento.
- El estudio revela un vínculo directo entre la presencia de patógenos y el comportamiento social alterado a través de vías neuronales específicas.
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