Video Experimental Relacionado

Updated: Sep 10, 2025

Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
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Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography

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Metalloproteinasa de matriz de tipo 5 de membrana (MT5-MMP): antecedentes y funciones propuestas en la fisiología

Deepak Jadhav1, Anna M Knapinska1, Hongjie Wang1

  • 1Institute for Human Health & Disease Intervention (I-HEALTH) and Department of Chemistry & Biochemistry, Florida Atlantic University, Jupiter, FL 33458, USA.

Biomolecules
|August 28, 2025
PubMed
Resumen

La metaloproteinasa de matriz de tipo 5 de membrana (MT5-MMP) actúa como una η-secretasa en la enfermedad de Alzheimer, rompiendo la proteína precursora amiloide (APP) y aumentando los fragmentos sinaptotóxicos. Se necesitan más investigaciones para definir sus sustratos y desarrollar inhibidores.

Palabras clave:
La enfermedad de AlzheimerMT5-MMPel cáncerMetalloproteinasa de matriz de tipo membrana

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