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Mucormicosis diseminada
Christopher V Radcliffe1, Elizabeth E Tremblay2, Francisco J Machiavello Roman1
1Section of Infectious Diseases, Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
IDCases
|February 20, 2026
Resumen
Las nuevas lesiones cutáneas en pacientes con trasplante de células madre requieren una evaluación cuidadosa de la mucormicosis invasiva. El diagnóstico temprano mediante biopsia y el tratamiento con anfotericina B, junto con la reconstitución inmune, son cruciales para mejores resultados.
Área de la Ciencia:
- Micología
- Enfermedades Infecciosas
- Hematología
Sus antecedentes:
- Los receptores de trasplantes de células madre son inmunocomprometidos y susceptibles a infecciones oportunistas.
- La mucormicosis invasiva es una infección fúngica rara pero potencialmente mortal.
- Las manifestaciones cutáneas pueden ser la presentación inicial de la mucormicosis invasiva.
Objetivo del estudio:
- Destacar la importancia de evaluar las nuevas lesiones cutáneas en receptores de trasplantes de células madre.
- Enfatizar las estrategias diagnósticas y terapéuticas para la mucormicosis invasiva en esta población.
Principales métodos:
- Revisión de presentaciones clínicas y enfoques diagnósticos para la mucormicosis invasiva.
- Discusión de las guías de tratamiento actuales y los factores pronósticos.
Principales resultados:
- Las nuevas lesiones cutáneas en receptores de trasplantes de células madre requieren un estudio exhaustivo.
- La biopsia de tejido es esencial para confirmar la mucormicosis invasiva.
- La anfotericina B es la terapia antifúngica empírica de primera línea recomendada.
- El manejo exitoso depende del diagnóstico temprano, el tratamiento antifúngico apropiado y la reconstitución inmune.
Conclusiones:
- La vigilancia de los signos cutáneos de mucormicosis invasiva es fundamental en pacientes con trasplante de células madre.
- A menudo se requiere un manejo multidisciplinario que involucre a especialistas en enfermedades infecciosas, hematólogos y dermatólogos.
- La optimización de la inmunidad del huésped es un componente clave para el tratamiento exitoso de la mucormicosis.
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