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関連する概念動画

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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関連する実験動画

Updated: Jul 4, 2026

An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis
08:09

An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis

Published on: September 15, 2015

プロテオミクスは,遺伝子やゲノムを研究するために用いられる.

A Pandey1, M Mann

  • 1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142, USA.

Nature
|June 24, 2000
PubMed
まとめ

タンパク質の大規模な研究であるプロテオミクスは,遺伝子機能の理解を助けます. タンパク質の識別,微分表示,相互作用の研究を含むもので,生物学的および疾患研究の有意義な見通しを提示しています.

科学分野:

  • バイオケミストリー バイオケミストリー
  • 分子生物学は分子生物学である.
  • ゲノミクスゲノミクスとは

背景:

  • ポストゲノム時代は,遺伝子機能を理解するための高度な方法を必要とします.
  • タンパク質分析,またはプロテオミクスは,生物学的プロセスを解明するために不可欠です.
  • 配列や構造だけでタンパク質の機能を予測するのは,大変な課題です.

研究 の 目的:

  • 遺伝子機能を理解する上でプロテオミクスの重要性を強調する.
  • プロテオミクスの主要分野と応用について概要を述べる.
  • 機能性タンパク質解析におけるプロテオミクスの可能性を強調する.

主な方法:

  • 大規模なタンパク質の識別と改変分析のためのタンパク質のマイクロ特徴化.
  • タンパク質発現レベルを比較するための微分表示プロテオミクス.
  • 質量スペクトロメトリーや酵母2ハイブリッドシステムなどの技術を用いたタンパク質-タンパク質相互作用の研究.

主要な成果:

  • プロテオミクスは,タンパク質分析に多面的なアプローチを提供します.
  • ディフェンシャルディスプレイプロテオミクスは,疾患研究における潜在的な応用がある.

さらに関連する動画

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

関連する実験動画

Last Updated: Jul 4, 2026

An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis
08:09

An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis

Published on: September 15, 2015

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

  • タンパク質複合体の構成要素を特定することは,機能プロテオミクス分析の核心です.

    • 結論:

    • プロテオミクスは,生物学的システムに関する理解を深めるために不可欠な分野です.
    • タンパク質複合体と細胞構造の研究は,大きな希望を持っています.
    • プロテオミクスは,タンパク質の生化学,プロセス,経路の理解に大きく貢献します.