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Reaction Kinetics and Combustion Dynamics of I4O9 and Aluminum Mixtures
Published on: November 7, 2016
インドメタシンの固体形態とアンモニアガスとの反応性の違い
Xiaoming Chen1, Kenneth R Morris, Ulrich J Griesser
1Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 47907-2051, USA.
Journal of the American Chemical Society
|December 12, 2002
まとめ
インドメタシンの固体形態は,アンモニアガスとの反応性が異なっています. 変形性および転移性アルファ形態は反応し,安定したガンマ形態は分子配置の違いのために惰性のままである.
科学分野:
- 固体化学 固体化学
- 医薬品科学とは,医薬品科学のことである.
- マテリアルサイエンス 材料科学
背景:
- インドメタシンのような非ステロイド性抗炎症薬 (NSAIDs) は,様々な固体形態で存在します.
- これらの形態の反応性を理解することは,薬剤の配方と安定性にとって極めて重要です.
研究 の 目的:
- 異なる固体形態のインドメタシンとアンモニアガスの酸塩反応を調査する.
- 結晶構造,分子配置,反応性との関係を明らかにする.
主な方法:
- X線粉の difrraction diffraction は,X線粉の difrraction diffraction で,X線粉の difrraction で X線粉の difrraction で X線粉の difrraction で X線粉の difrraction で X線粉の difrraction で X線粉の difrraction で X線粉の difrraction で X線粉の difrraction で X線粉の difrraction で X線粉の difrraction で X線粉の difrraction で X線粉の difrraction で
- 光学顕微鏡による光学顕微鏡です.
- グラビメトリー・グラビメトリー
- スペクトロスコーピーの方法
主要な成果:
- アモルフォスインドメタシンは,アンモニアガスと素早く反応して,アモルフォスアンモニアム塩を形成します.
- メタステーブルなアルファ形態は反応して,微結晶のアンモニアム塩を産生し,ア軸に沿ってアニゾトロプ的伝播をします.
- 安定したガンマ形態は,その結晶構造により,アンモニアガスに対して惰性である.
結論:
- インドメタシンの固体形態とアンモニアガスの反応性は,包装密度ではなく,分子配列に依存しています.
- アルファ形態の露出したカルボキシル酸群は反応を促進するが,ガンマ形態では遮断されている.
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