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関連する概念動画

Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze the...
Sympathetic Signaling01:31

Sympathetic Signaling

Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...

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Updated: Jul 21, 2026

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics
09:25

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

Published on: December 24, 2015

ミオサイト・アドレノ受容体シグナル伝達経路

Yang Xiang1, Brian K Kobilka

  • 1Department of Molecular and Cellular Physiology, Stanford Medical Center, Palo Alto, CA 94305, USA.

Science (New York, N.Y.)
|June 7, 2003
PubMed
まとめ

アドレノ受容体 (ARs) は心臓機能を調節しますが,心不全では損傷を引き起こす可能性があります. 特定のARシグナル伝達経路を理解することは,心臓の健康と疾患におけるその役割の鍵です.

科学分野:

  • 心血管生理学 心血管の生理学
  • 分子心臓病学 分子心臓病学
  • Gタンパク質結合受容体のシグナル伝達

背景:

  • アドレノ受容体 (ARs) は,交感神経系と心血管系を接し,心筋機能の急速な調節に不可欠です.
  • 心不全におけるARsの慢性刺激は,ミオサイトアポトーシスおよび高縮を含む有害な心臓リモデリングと関連しています.
  • 心臓のミオサイトにおけるARサブタイプの活性化は,Gタンパク質の異なる結合と特定の下流信号伝達経路につながる.

研究 の 目的:

  • 個々のアドレノ受容体亜型の特定のシグナル伝達経路を解明する.
  • 心筋のアドレネルギーシグナル伝達におけるアドレノ受容体サブタイプのインビボ機能を理解する.
  • 筋細胞のアドレネルギー信号伝達経路内の接続をマッピングする.

主な方法:

  • Gタンパク質結合受容体スーパーファミリーのメンバーの分析.
  • 心筋細胞におけるアドレノ受容体亜型分布の調査.
  • プラズマ膜のコンパートメント内のシグナル伝達分子複合体の検査.
  • アドレナジックおよびミオサイトアドレナジックシグナル伝達経路のための接続マップの開発.

主要な成果:

  • 個々のアドレノ受容体のサブタイプは,異なるGタンパク質とカップリングする.

さらに関連する動画

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

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Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles
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Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles

Published on: November 3, 2023

関連する実験動画

Last Updated: Jul 21, 2026

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics
09:25

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

Published on: December 24, 2015

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles
08:04

Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles

Published on: November 3, 2023

  • サブタイプ固有の受容体分布は,シグナル伝達経路誘導に影響を与える.
  • 膜区間の特定のシグナル伝達複合体は,アドレネルギー反応を調節する.
  • 接続 マップは,異なるARサブタイプのシグナリングと機能を視覚化します.

    • 結論:

    • 個々のARサブタイプの特定のシグナル伝達経路を理解することは,正常な心機能と心不全におけるそれらの役割を理解するために重要です.
    • ARsと関連するシグナル伝達分子の分割は,機能的結果を決定する.
    • これらの経路の詳細なマッピングは,心血管疾患の潜在的な治療目標の洞察を提供します.