ハイドロフォビック化合物のデンドライト分子カプセル
Meredith T Morgan1, Michael A Carnahan, Chad E Immoos
1Departments of Chemistry and Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Journal of the American Chemical Society
|December 11, 2003
まとめ
ポリ (グリセロール succinic acid) デンドリマーが Reichardt を成功裏に封じ込めました.
科学分野:
- 超分子化学 超分子化学
- マテリアルサイエンス 材料科学
- ナノテクノロジー ナノテクノロジー
背景:
- デンドリマは,高度に枝分かれしたマクロ分子で,調整可能な内部環境を持っています.
- デンドリマー内のマイクロ環境を調査することは,その性質と応用を理解するために不可欠です.
- Reichardtの染料は,極性および局所的介電定数に対する敏感な探知器である.
研究 の 目的:
- 封装されたライハルトの染料を用いてポリ (グリセロール succinic acid) のデンドリマーの内部環境を特徴付けるために.
- これらのデンドリマーが,水溶性の低い薬剤の投与媒介としての可能性を評価する.
主な方法:
- ポリ (グリセロール succinic acid) デンドリマー ([Gn]-PGLSA-OH) の内部にライハルトの染料の封じ込め.
- UV-Vis吸収,1H NMR,T1/T2のリラックス時間,および1H NOESYを含むスペクトル解析.
- カーボキシ化されたPGLSAデンドリマー ([G4]-PGLSA-COONa) の内部に10-ヒドロキシカンプトセチン (10HCPT) を封じ込みました.
- ヒト乳がん細胞を用いたインビトロ細胞毒性アッセイ.
主要な成果:
- 封装されたライハルトの染料は,デンドリマー内の高い介電常数を示した.
- NMRデータは,染料の dendrimer内の近接と制限された動きを確認しました.
- 封装された10HCPTは,乳がん細胞に対する有意な細胞毒性を示し,その活性を維持しました.
- カーボキシル化デンドリマー ([G4]-PGLSA-COONa) は,抗がん剤の投与に成功しました.
結論:
- ポリ (グリセロール succinic acid) デンドリマーは,ゲスト分子のための閉じ込められたマイクロ環境を提供します.
- これらのデンドリマーは,水害性抗がん剤の有効な薬物投与システムとして有望を示しています.
- 封装された薬は治療効果を保持し,デンドリマーベースの薬剤投与の可能性を強調しています.
関連する概念動画
Solvents
A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
A...
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Cohesion
Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
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Molecular Shape and Polarity
Dipole Moment of a Molecule
Solubility
Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
Colloidal precipitates
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
Colligative Properties
When a solute is added to a pure solvent (A), the mole fraction of A decreases. The mole fraction is the ratio of the number of moles of A to the total number of moles in the solution. This decrease in mole fraction leads to a reduction in A's chemical potential (μA).The changes in μA also affect the solution's colligative properties. Colligative properties are properties of a solution that depend only on the number of solute particles present, not their identity. Examples include boiling point...


