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Murine Nasal Lavage Fluid Collection without Blood Contamination

Murine Nasal Lavage Fluid Collection without Blood Contamination

The present protocol describes a novel method for avoiding blood contamination in murine nasal lavage fluid (NLF). Since this method ensures the NLF collection without blood contamination, it allows for more accurate detections of immunological components and various respiratory...

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

OSTSS leads to pooled inflammatory mediators in the tear film, causing symptoms like epiphora and discomfort. Here, we present a case where therapeutic nasolacrimal lavage every 2 months resolved epiphora and itchiness, suggesting its efficacy as a therapeutic intervention for OSTSS. Additionally, we report subjective improvements in symptoms in 3 additional...

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Saline nasal lavage can be used to sample the canine nasal immune microenvironment. Because the approach is relatively non-invasive and does not disrupt the nasal tissues, it can be performed serially. Cells and proteins collected from the nasal lavage technique can be processed for various laboratory analyses.

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

A protocol for conducting a challenge in an allergen exposure chamber (AEC) facility is presented. AECs have proven to be safe and effective tools for the induction of allergic symptoms or as an endpoint in the efficacy testing of allergen immunotherapy due to their ability to maintain stable particle concentrations and environmental...

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Batrachochytrium dendrobatidis infection in amphibians can be eliminated using a reduced concentration (0.0025%) and shorter duration (five minute baths for six days) of itraconazole than is generally used. Less mortality and fewer negative side effects were observed using this modified treatment...

Intranasal Administration of CNS Therapeutics to Awake Mice

Intranasal Administration of CNS Therapeutics to Awake Mice

A method to intranasally administer drugs to awake mice for the purpose of targeting the brain is described. This method allows for repeat dosing over long periods using intranasal administration of drug without anesthesia, and nose-to-brain delivery with minimal systemic...

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Updated: Jan 7, 2026

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

RNAポリメラーゼにおけるアクティブサイトダイナミクス

Robert Landick¹

¹Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.

|March 16, 2004

まとめ

新しい研究によると,バクテリオファージT7RNAポリメラーゼは,DNAポリメラーゼに似たヌクレオチド添加サイクルを使用している. この発見は,他の生物における複雑なRNAポリメラーゼについての洞察を提供します.

科学分野:

バイオケミストリーバイオケミストリー
分子生物学は分子生物学である.
構造生物学構造生物学とは

背景:

バクテリオファージT7RNAポリメラーゼは,ウイルスの遺伝子発現における重要な酵素である.
RNAポリメラーゼ機構の理解は,細胞転写の解読に不可欠です.

さらに関連する動画

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

Intranasal Administration of CNS Therapeutics to Awake Mice

Intranasal Administration of CNS Therapeutics to Awake Mice

Published on: April 8, 2013

関連する実験動画

Last Updated: Jan 7, 2026

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

Intranasal Administration of CNS Therapeutics to Awake Mice

Intranasal Administration of CNS Therapeutics to Awake Mice

Published on: April 8, 2013