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Updated: Jul 8, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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タンパク質の構造と動態を同時に決定する

Kresten Lindorff-Larsen1, Robert B Best, Mark A Depristo

  • 1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

Nature
|January 15, 2005
PubMed
まとめ

この研究は,核磁共鳴スペクトロスコピーと分子動態シミュレーションを組み合わせた新しい方法を導入し,タンパク質の構造と動態を明らかにします. ヒトのユビキチンには様々な形状があり,密集した内部が液体のような振る舞いを示すことを示しています.

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Protein Organization01:13

Protein Organization

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Protein Folding01:22

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Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.