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ハダマード光譜を用いた 2D NMR リガンドの迅速なスクリーニング

Miguel Feliz1, Jesús García, Eric Aragón

  • 1Laboratory of Biomolecular NMR, Institute of Research in Biomedicine, Science Research Park, Josep Samitier 1-5, 08028 Barcelona, Spain.

Journal of the American Chemical Society
|June 1, 2006
PubMed
まとめ

ハダマード暗号化スペクトロスコピーは,特定の信号に焦点を当てることで,2D NMRの迅速なスクリーニングを可能にします. この方法は,ハダマード星座のピーク強度を使用して,リガンド誘発のシフトを定量化し,薬剤発見を加速します.

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