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Updated: Jul 12, 2026

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
12:05

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

Published on: March 6, 2013

マクロサイクルベータシートペプチドは,分子間ベータシート相互作用を通じて,タンパク質四次構造を模倣する

Omid Khakshoor1, Borries Demeler, James S Nowick

  • 1Department of Chemistry, University of California-Irvine, Irvine, California 92697-2025, USA.

Journal of the American Chemical Society
|April 11, 2007
PubMed
まとめ

この研究では,タンパク質の四分構造を模倣して,ベータシート構造に自己組み立てられるサイクルペプチドを設計しました. これらのペプチドは,特定の配列の変異によってテトラメアを形成し,折り畳みとオリゴメリゼーションのための重要な残基を明らかにします.

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