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Updated: Jul 19, 2026

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
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ウビキチン結合タンパク質RAP80は,BRCA1依存のDNA損傷反応を媒介する

Hongtae Kim1, Junjie Chen, Xiaochun Yu

  • 1Department of Therapeutic Radiology, Yale University School of Medicine, Post Office Box 208040, New Haven, CT 06520, USA.

Science (New York, N.Y.)
|May 26, 2007
PubMed
まとめ

受容体関連タンパク質80 (RAP80) は,乳がん感受性遺伝子1 (BRCA1) と相互作用して,DNA修復を助ける. この発見は,DNA損傷に対する細胞の反応に不可欠な,ユビキチネーションに依存する経路を明らかにしています.

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