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RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...

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Updated: Jul 4, 2026

Nanomanipulation of Single RNA Molecules by Optical Tweezers
06:59

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

RNAヘアピン折り畳みの中間物質に関する構造的洞察

Gregory R Bowman1, Xuhui Huang, Yuan Yao

  • 1Biophysics Program, Stanford University, Stanford, California 94305, USA.

Journal of the American Chemical Society
|July 3, 2008
PubMed
まとめ

分子機能に不可欠なRNAヘアピンには,複数の状態を経て折りたたみがある. シミュレーションにより,中間構造が明らかになり,折り畳みは,生物分子プロセスにおける一般的な特徴である展開の単純な逆ではないことを示唆しています.

科学分野:

  • 分子生物学は分子生物学である.
  • バイオフィジックス 生物物理学
  • コンピューティング・ケミストリー

背景:

  • RNAヘアピンとは,RNA分子における基本的な二次構造である.
  • RNAヘアピン (二状態対複数状態) の折り畳みメカニズムはまだ研究中です.
  • ヘアピン折り合いを理解することは,RNAの構造と機能の関係を理解する鍵です.

研究 の 目的:

  • 小さなテトラループのヘアピンの折り畳み経路を調査するために.
  • ヘアピン折り畳みは2つの状態または複数の状態のモデルに従っているかどうかを判断する.
  • 折りたたみ過程で潜在的な中間構造を特定する.

主な方法:

  • レプリカ交換分子動力学 (REMD) のシリアルバージョンを使用しました.
  • 強化されたシミュレーション機能のための分散コンピューティング環境を使用.
  • 折りたたみの中間物質を特定するために,シミュレーション軌道を分析しました.

主要な成果:

  • ヘアピン折り畳み中にいくつかの中間構造を特定しました.
  • これらの中間物質は,既存の実験データと一致しています.

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Practical Aspects of Sample Preparation and Setup of 1H R1ρ Relaxation Dispersion Experiments of RNA
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Visualization and Quantification of Intermolecular RNA Base Pairing in in vitro RNA Clusters Using Split Broccoli RNA Reporters
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Visualization and Quantification of Intermolecular RNA Base Pairing in in vitro RNA Clusters Using Split Broccoli RNA Reporters

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関連する実験動画

Last Updated: Jul 4, 2026

Nanomanipulation of Single RNA Molecules by Optical Tweezers
06:59

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

Practical Aspects of Sample Preparation and Setup of 1H R1ρ Relaxation Dispersion Experiments of RNA
08:17

Practical Aspects of Sample Preparation and Setup of 1H R1ρ Relaxation Dispersion Experiments of RNA

Published on: July 9, 2021

Visualization and Quantification of Intermolecular RNA Base Pairing in in vitro RNA Clusters Using Split Broccoli RNA Reporters
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Published on: May 29, 2026

  • 折り畳みの経路は,高温展開の単純な逆転ではないことを観察しました.

    • 結論:

    • RNAのヘアピン折り畳みは,一時的な中間体を含む複数の状態を経て進行する可能性があります.
    • 折り畳み経路は,展開経路と大きく異なる可能性があります.
    • この複雑な折り畳みメカニズムは,生物分子折り畳みプロセスの一般的な特徴かもしれません.