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Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...

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Updated: Jul 3, 2026

Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts
10:04

Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts

Published on: January 8, 2017

細胞増殖へのパスポート

Eitan Zlotorynski1, Reuven Agami

  • 1The Netherlands Cancer Institute, Division of Gene Regulation, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

Cell
|July 30, 2008
PubMed
まとめ
この要約は機械生成です。

代替的ポリアデニレーションは,3'未翻訳領域が特徴的なメッセンジャーRNA (mRNA) 変種を生成する. このプロセスは,マイクロRNAの調節と細胞増殖と関連しており,世界的に遺伝子発現に影響を与えています.

さらに関連する動画

High-throughput Imaging and Analysis Workflow for Evaluating Skin Cell Phenotypes and Proliferation States in Tissue Samples
11:24

High-throughput Imaging and Analysis Workflow for Evaluating Skin Cell Phenotypes and Proliferation States in Tissue Samples

Published on: October 31, 2025

Isolation and Staining of Mouse Skin Keratinocytes for Cell Cycle Specific Analysis of Cellular Protein Expression by Mass Cytometry
12:34

Isolation and Staining of Mouse Skin Keratinocytes for Cell Cycle Specific Analysis of Cellular Protein Expression by Mass Cytometry

Published on: May 9, 2019

関連する実験動画

Last Updated: Jul 3, 2026

Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts
10:04

Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts

Published on: January 8, 2017

High-throughput Imaging and Analysis Workflow for Evaluating Skin Cell Phenotypes and Proliferation States in Tissue Samples
11:24

High-throughput Imaging and Analysis Workflow for Evaluating Skin Cell Phenotypes and Proliferation States in Tissue Samples

Published on: October 31, 2025

Isolation and Staining of Mouse Skin Keratinocytes for Cell Cycle Specific Analysis of Cellular Protein Expression by Mass Cytometry
12:34

Isolation and Staining of Mouse Skin Keratinocytes for Cell Cycle Specific Analysis of Cellular Protein Expression by Mass Cytometry

Published on: May 9, 2019

科学分野:

  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは
  • 遺伝子規制 遺伝子規制

背景:

  • 代替ポリアデニレーション (APA) は,異なるメッセンジャーRNA (mRNA) の同型を生成する.
  • これらの異形は,異なる3'未翻訳領域 (3'UTR) を有する.
  • 特に遺伝子調節におけるAPAの機能的影響は,活発な研究分野である.

研究 の 目的:

  • 代替ポリアデニレーションとマイクロRNA媒介遺伝子調節との関連を調査する.
  • 細胞増殖のグローバルプログラムにおけるAPAの役割を調査する.

主な方法:

  • 3'UTRが異なるmRNA同型の分析.
  • これらのアイソフォーム内のマイクロRNA結合部位の検査.
  • APAパターンと細胞増殖率の相関.

主要な成果:

  • 証拠は,代替的なポリアデニレーション部位がマイクロRNAの調節と関連していることを示唆しています.
  • APAは,細胞増殖を規制するより広範な規制メカニズムに貢献します.
  • APAによって生成された特定のmRNAアイソフォームは,遺伝子発現を制御するためにmicroRNAによって標的にされることがあります.

結論:

  • 代替ポリアデニレーションは,マイクロRNA媒介による遺伝子発現制御において重要な役割を果たします.
  • APAは,細胞増殖プログラムの重要な構成要素として関与しています.
  • APA-microRNAの相互作用を理解することは,細胞の成長と分裂の調節に関する洞察を提供します.