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関連する概念動画

Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is critical for...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-Term Memory01:18

Long-Term Memory

Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

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関連する実験動画

Updated: Jun 20, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

ドーパミンは,長期記憶の保存の持続性を制御する.

Janine I Rossato1, Lia R M Bevilaqua, Iván Izquierdo

  • 1Centro de Memória, Instituto do Cérebro, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.

Science (New York, N.Y.)
|August 22, 2009
PubMed
まとめ

長期記憶の持続性は,海馬内の特定のドーパミンD1受容体活性に依存しています. 学習後の臨界時にこのシステムを操作することで,記憶の持続時間を制御することができます.

科学分野:

  • 神経科学は神経科学である.
  • 分子生物学は分子生物学である.
  • 行動科学は,行動科学である.

背景:

  • 長期記憶 (LTM) の持続性は重要な特徴ですが,その背後にあるメカニズムはまだ不明です.
  • LTMの持続時間に影響を与える要因を理解することは,記憶の研究にとって極めて重要です.

研究 の 目的:

  • 長期恐怖記憶の持続を調節するヒポカンプスのドーパミンD1受容体の役割を調査する.
  • LTMの統合と崩壊に関与する重要な時間窓と分子経路を特定する.

主な方法:

  • ネズミは恐怖の条件付けタスクに訓練されました.
  • ドーパミンD1受容体アンタゴニスト (SCH23390) またはアゴニスト (SK38393) は,トレーニング後の異なる時間点で,背面ヒポキャンパスに投与されました.
  • 脳由来ニューロトロフィックファクター (BDNF) レベルと内側帯領域 (VTA) 調節が評価されました.

主要な成果:

  • SCH23390の投与は,トレーニング後の12時間,ただちにまたは9時間後ではなく,LTMの恐怖の急速な衰退を引き起こしました.
  • SK38393の投与は,臨時的な恐怖記憶を持続的なものに変換しました.
  • これらの効果はBDNFによって媒介され,VTAによって調節された.

さらに関連する動画

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus
09:36

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

Published on: September 9, 2020

関連する実験動画

Last Updated: Jun 20, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus
09:36

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

Published on: September 9, 2020

結論:

  • 長期恐怖記憶の持続は,VTA/ヒポカンプスドーパミン作用結合の活性化に依存しています.
  • このドーパミン作用系の特定の操作により,学習後の間隔を定義することで,LTMの持続時間を調節することができます.