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Updated: May 8, 2026

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Published on: April 3, 2012

KAP1は,胚性幹細胞の内生レトロウイルスを制御する

Helen M Rowe1, Johan Jakobsson, Daniel Mesnard

  • 1School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

Nature
|January 16, 2010
PubMed
まとめ

KRAB関連タンパク質1 (KAP1) は,発達の初期に内生レトロウイルス (ERV) を制御する. ネズミの胚性幹細胞および胚におけるKAP1の欠失は,ERVの有意なアップレギュレーションを引き起こし,ゲノム完全性におけるその役割を強調する.

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