遺伝子発現の変動が,不完全な穿透率の基礎となっている
Arjun Raj1, Scott A Rifkin, Erik Andersen
1Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Nature
|February 19, 2010
まとめ
発達中の遺伝子発現のランダム性は,遺伝的に同一の生物でも,有意な表型変化を引き起こす可能性があります. 変異は,この隠された変動性を明らかにし,細胞の運命決定に影響を与える可能性があります.
科学分野:
- 発達生物学 発達生物学とは
- 遺伝学 遺伝学とは
- 分子生物学は分子生物学である.
背景:
- フェノタイプの変化は,遺伝的および環境的要因から生じる.
- 発達中のストキャスティック遺伝子発現も多様性を生み出すことができます.
- ネマトドのCaenorhabditis elegansは,発達の遺伝子ネットワークを研究するためのモデルを提供します.
研究 の 目的:
- 多細胞生物における遺伝子発現変動の影響を調査する.
- C. elegans. の腸内特異性におけるストキャスティシティの役割を調査する.
- 変異が遺伝子発現と現象的結果にどのように影響するかを理解する.
主な方法:
- Caenorhabditis elegansの腸内特異性を研究した.
- 変異性胚における遺伝子発現の変動性を分析した.
- 発達ネットワークにおける重要な遺伝子の量化トランスクリプトレベル.
主要な成果:
- 腸の特異性ネットワークの変異は,冗長な遺伝子の非常に変異的な発現につながった.
- この変動性は,ある値を超え,マスターレギュレータ遺伝子のON/OFF発現パターンを引き起こした.
- ストキャスティック遺伝子発現の変動性は,通常はバッファリングされ,突然変異によって露出され,現象型変異を引き起こしました.
結論:
- 発達ネットワークの変異は,バッファリングされたストキャスティック変動性を明らかにすることができます.
- この遺伝子発現の変動は,有意な表型差異につながる可能性があります.
- 遺伝子発現のランダム性は,多細胞生物の多様性を生み出す上で重要な役割を果たします.
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