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関連する概念動画

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

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関連する実験動画

Updated: May 16, 2026

Chromatin Isolation by RNA Purification (ChIRP)
11:09

Chromatin Isolation by RNA Purification (ChIRP)

Published on: March 25, 2012

長い非コーディングRNAによる表遺伝子調節.

Jeannie T Lee1

  • 1Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02138, USA. lee@molbio.mgh.harvard.edu

Science (New York, N.Y.)
|December 15, 2012
PubMed
まとめ
この要約は機械生成です。

哺乳類のゲノムは複雑で,多くの転写ユニットで,コード遺伝子が重なり合う長いノンコーディングRNA (lncRNA) が生成されます. これらのlncRNAの多様な機能を理解することは,分子生物学における重要な課題です.

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

関連する実験動画

Last Updated: May 16, 2026

Chromatin Isolation by RNA Purification (ChIRP)
11:09

Chromatin Isolation by RNA Purification (ChIRP)

Published on: March 25, 2012

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

科学分野:

  • ゲノミクスゲノミクスとは
  • 分子生物学は分子生物学である.
  • RNA 生物学 RNA 生物学

背景:

  • 最近の研究では,哺乳類のゲノムに浸透し,複雑に転写されていることが明らかになった.
  • 多くの転写ユニット,主にロングノンコーディングRNA (lncRNAs) を生成し,従来のコーディング遺伝子を重複しています.
  • lncRNAは,アンチセンセ,イントロニック,インタージェニックトランスクリプト,シドゲン,レトロトランポゾンなど,様々な種類を網羅しています.

研究 の 目的:

  • 膨大な数の lncRNA の機能的意義を探求する.
  • lncRNAが機能的分子なのか,それとも単なる転写副産物なのかを調査する.
  • lncRNAの機能とメカニズムの新興の景観を垣間見ることができます.

主な方法:

  • 哺乳類のゲノム転写に関する最近の研究のレビュー.
  • 新興のロングノンコーディングRNA (lncRNA) システムの分析.
  • lncRNAの機能とメカニズムを比較的に検討する.

主要な成果:

  • 哺乳類のゲノムの転写は非常に複雑で,lncRNAsとコーディング遺伝子の間の広範な重複があります.
  • lncRNAsの機能とメカニズムは,多様でほとんど未知の領域を表しています.
  • トランスクリプションユニットの有意な部分は,lncRNAsを生成し,それらは単なる副産物であるという概念に異議を唱える.

結論:

  • lncRNAsの機能的役割は多様で,まだ完全に理解されていません.
  • lncRNAの機能とメカニズムの"ワイルドウエスト"の風景を明らかにするために,さらなる研究が不可欠です.
  • これらのマクロ分子を理解することは,将来の分子生物学研究の重要な課題です.