循環する乳がん細胞は,上皮細胞と中皮細胞の組成にダイナミックな変化を示す
Min Yu1, Aditya Bardia, Ben S Wittner
1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
まとめ
エピセリアル-メゼンキマトランジション (EMT) は腫瘍転移を促します. 乳がん患者では,メゼンキマ循環腫瘍細胞 (CTC) が濃縮され,疾患進行と関連しており,EMTを示唆しています.
科学分野:
- 腫瘍学 腫瘍学
- 細胞生物学 細胞生物学
- 癌の転移 メタスタシス
背景:
- エピセリアル-メゼンキマトランジション (EMT) は,前臨床モデルにおける腫瘍転移に関連した細胞プロセスである.
- 人間の癌の進行,特に循環腫瘍細胞 (CTC) の進行におけるEMTの役割については,さらなる調査が必要である.
研究 の 目的:
- 乳がん患者のCTCにおけるEMTの特徴を明らかにする.
- メゼンキーマCTCと疾患の進行との関連を調査する.
主な方法:
- 乳がん患者のCTCにおけるEMTマーカーの特徴.
- 治療を受けている患者のCTCの連続モニタリング.
- メゼンキーマCTCにおけるEMTレギュレータの分析.
主要な成果:
- メゼンキマ細胞は,原発性腫瘍と比較して,CTCに高度に濃縮されていました.
- 連続CTCモニタリングは,メゼンキマCTCと疾患の進行との関連性を示した.
- 逆戻り可能なEMTシフトは,治療応答と進行と相関するインデックス患者で観察されました.
- メセンキマCTCは単細胞およびクラスターとして発見され,TGF-β経路成分およびFOXC1.1のようなEMT調節体を発現した.
結論:
- EMTは,ヒトの乳がんの血液による拡散に役割を果たしています.
- メセンキマCTCは,疾患進行および治療応答のバイオマーカーとして機能する可能性があります.
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