Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

1.5K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
1.5K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

1.4K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.4K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.1K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.1K
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

1.3K
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
1.3K
Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

6.1K
The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
6.1K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.0K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.0K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion.

Nature genetics·2026
Same author

Functional chromatin signatures premark future lineage-specific enhancers.

Cell genomics·2026
Same author

Feeder-free yet still naïve: improved method for capturing human pluripotent stem cells.

The EMBO journal·2026
Same author

Post-replicative chromatin accessibility predicts cell fate change.

Stem cell reports·2026
Same author

Morphomechanic tuning of ERK by actin-TFII-IΔ regulates cell identity.

bioRxiv : the preprint server for biology·2026
Same author

Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration.

Nature communications·2026
Same journal

Six ways to put the public at the heart of science and policy.

Nature·2026
Same journal

The complex truth about trust in science.

Nature·2026
Same journal

Have people stopped trusting science? The data tell a surprising story.

Nature·2026
Same journal

How FAIR data are helping to build trust in science.

Nature·2026
Same journal

Scientists should recognize their own political biases to build public trust.

Nature·2026
Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026
関連記事をすべて見る

関連する実験動画

Updated: May 6, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.7K

細胞の再プログラミング中のクロマチンの動態

Effie Apostolou1, Konrad Hochedlinger

  • 11] Massachusetts General Hospital Center for Regenerative Medicine, 185 Cambridge Street, Boston, Massachusetts 02114, USA. [2] Harvard Stem Cell Institute, 1350 Masschusetts Avenue, Cambridge, Massachusetts 02138, USA. [3] Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 20815, USA. [4] Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

Nature
|October 25, 2013
PubMed
まとめ
この要約は機械生成です。

誘発性多能性は,患者特有の幹細胞を生成し,転写因子とクロマチンの構造に関する洞察を明らかにします. これらのダイナミクスを研究することで,再生医療とがん治療の進歩を図る可能性がある.

さらに関連する動画

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.1K
CRISPR-Mediated Reorganization of Chromatin Loop Structure
09:20

CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

14.2K

関連する実験動画

Last Updated: May 6, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.7K
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.1K
CRISPR-Mediated Reorganization of Chromatin Loop Structure
09:20

CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

14.2K

科学分野:

  • * 幹細胞生物学と表遺伝学.
  • * 細胞運命を決定する分子機構.

背景:

  • * 誘発性多能性 (iPSC) 技術は,患者特有の幹細胞生成を可能にします.
  • * iPSC技術は,転写因子とクロマチンの相互作用を研究するためのモデルを提供します.
  • *クロマチンのダイナミクスを理解することは,細胞状態の移行に不可欠です.

研究 の 目的:

  • * 誘発性多能性におけるクロマチンの動態に関する最近の進歩をレビューする.
  • * iPSCの染色体イベントと生殖細胞の成熟と腫瘍発生を比較するために.
  • * 再生医療とがん治療における潜在的な応用を探求する.

主な方法:

  • * 誘発性多能性およびクロマチンの動態に関する現在の文献のレビュー.
  • * iPSC,生殖細胞,腫瘍におけるクロマチンの改造の比較分析.
  • * 統合されたメカニズム的洞察を提案するために,発見の合成.

主要な成果:

  • *クロマチンは,多能性の誘導中に重要な動的変化を経験します.
  • * 多能性,生殖細胞の発達,がんにおけるクロマチンの改造プロセスには類似点がある.
  • *これらのダイナミックなクロマチンのイベントは,細胞の運命を調節する鍵です.

結論:

  • *誘発性多能性は,基本的な細胞生物学を研究するための貴重な枠組みを提供します.
  • * 多様なプロセスにおけるクロマチンのダイナミクスの統合的な見方は,新たな治療戦略を生み出せる.
  • *さらなる研究により,新たな再生医療とがん治療のアプローチが明らかになる可能性があります.