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同義変異は,ヒトの癌の原動力変異として頻繁に作用する

Fran Supek1, Belén Miñana2, Juan Valcárcel3

  • 1EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation, Dr. Aiguader 88, 08003 Barcelona, Spain; Centre for Genomic Regulation, Universitat Pompeu Fabra, Barcelona 08003, Spain.

Cell
|March 18, 2014
PubMed
まとめ

以前は"静かな"と考えられていた同義変異は,遺伝子スプライシングに影響することで,ヒトの癌に大きく寄与する. これらの突然変異は,腫瘍遺伝子や腫瘍抑制剤で選択され,がんの発症に影響を与えます.

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