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Author Spotlight: RNAi Inheritance and ChIP in C. elegans
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世代を超えたエピジェネティック遺伝:神話とメカニズム
Edith Heard1, Robert A Martienssen2
1Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d'Ulm, 75248 Paris Cedex 05, France; Collège de France, 11 place Marcelin-Berthelot, Paris 75005, France.
Cell
|April 1, 2014
まとめ
環境要因は遺伝子発現と健康に影響を及ぼしますが,これらの表遺伝的変化がヒトの子孫に伝わるかどうかは,植物における証拠にもかかわらず,まだ不明です.
科学分野:
- 遺伝学と分子生物学について
- 環境衛生 環境衛生 環境衛生
背景:
- 人間のゲノムの配列決定は,エピジェネティクスへの関心を呼び起こし,遺伝子コードを超えた影響力を探求した.
- エピジェネティクスは,食事,空気質,感情などの環境要因が遺伝子発現にどのように影響するかを研究しています.
研究 の 目的:
- 環境要因が遺伝子発現に影響を与える可能性を検証する.
- 人間における世代を超えたエピジェネティック継承の範囲を明らかにする.
主な方法:
- エピジェネティクスと環境の影響に関する現在の科学文献のレビュー.
- 植物とヒトにおける表遺伝子遺伝を調査する研究の分析.
主要な成果:
- 環境要因は明らかに遺伝子発現に影響を及ぼし,病気に寄与する可能性があります.
- 植物では表遺伝的特徴の遺伝が確認されている.
- 人間における環境によって誘発された世代を超えた表遺伝的遺伝の範囲は,依然として大きく未決定のままである.
結論:
- 環境要因は遺伝子発現に影響を及ぼしますが,ヒトにおける世代を超えた影響については,さらなる調査が必要です.
- 人間の世代を超えた表遺伝子遺伝のメカニズムと流行を理解するために,さらなる研究が必要である.
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