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Updated: Apr 25, 2026

Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins
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Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins

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人間のcGASの構造誘導型再プログラミング ディヌクレオチド結合特異性

Philip J Kranzusch1, Amy S Y Lee2, Stephen C Wilson3

  • 1Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute (HHMI), University of California, Berkeley, Berkeley, CA 94720, USA.

Cell
|August 19, 2014
PubMed
まとめ

この研究は,細菌の酵素とヒトのcGASが,特定の結合を持つ周期性ダイヌクレオチド (CDN) を合成する方法を示しています. このメカニズムを理解することで,細菌の病原性および先天性免疫経路が明らかになる.

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