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Assembly and Characterization of Polyelectrolyte Complex Micelles
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オリゴヌクレオチドにブラッシュ・ポリマー・アシスト・コンパクションによるステリック・セレクティビティを提供

Xueguang Lu1, Thanh-Huyen Tran1, Fei Jia1

  • 1Department of Chemistry and Chemical Biology and ‡Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University , Boston, Massachusetts 02115, United States.

Journal of the American Chemical Society
|September 18, 2015
PubMed
まとめ

新しいブラシポリマー/DNA結合物は,タンパク質の相互作用を減らし,生物分布を改善することによって,オリゴヌクレオチドの治療効果を高めます. これらのナノ構造は 安定性を向上させ 先進的な治療の副作用を軽減します

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